Brain
Waves
How a UM doctor may soon unveil the ultimate cure for addictions,
and uncovered the mystery surrounding sudden cocaine deaths
Beneath a brilliant vault of stars, a young
man is sitting on a rug somewhere out in the South African veldt. But he only
has eyes for the extraordinary parade of images inside his head. There is
a tremor to his legs that makes it hard to stand and he's regularly gripped
by waves of nausea. However, none of that matters.
By Nina L. Diamond. Photograph by
Jane Mitchell
For several hours all his attention has been focused inwards, on scenes from
his childhood, many of them painful... his mother shouting at him the time
his father left: he sees their flushed faces, hears their harsh words, feels
his own fear and anger. It's only a memory, but it's a turbocharged memory.
Think holiday snap compared with a film shot in Imax.
He's taken a drug, of course, but one that is not illegal. The sheer intensity
of the ibogaine experience is something that even the most voracious drug-taker
would only want once or twice in a lifetime. In fact he is taking it as a
one-off cure for a heavy heroin habit. Not only does ibogaine give you psychological
insights that normally come only after months of therapy, but it takes away
all craving for the drug of choice - heroin, cocaine, alcohol, nicotine.
The man on the blanket is one of scores of addicts who, over the last few
years, have taken ibogaine while in the grip of a $l00-a-day habit, and emerged
30 hours later, free of a desire to take it and with none of the dreadful
symptoms of withdrawal. A group calling themselves INTASH (International Addict
Self-Help) are enthusiastic about the drug. "In the world today there is no
substance as effective in combatting opiate narcotics, stimulants, alcohol
and nicotine addiction as ibogaine. Being prepared for treatment with ibogaine
means being ready and willing to take a physical and spiritual leap forward,"
said a spokesperson.
Ibogaine is one of several alkaloids found in the West African shrub called
Tabernanthe Iboga. The first reports of it came from French and Belgian explorers
in the the last century. "ln small quantities it is an aphrodisiac and a stimulant
of the nervous system," wrote one traveler in 1864. "Warriors and hunters
use it constantly to keep them awake during the night watches."
These travelers took it home, which is why, like coffee or cocoa, it was first
used in the West as a tonic. French chemists crystallized it at the turn of
the 20th century (about the same time cocaine was crystallized from cocoa)and
it was used as a treatment for sleeping sickness and for convalescents. Pills
containing 8mg of ibogaine were sold in France in the 1930s under the Lambarene
trademark. It was claimed they got rid of fatigue and improved appetite. 
The iboga was initially used by the Mitsogho, a tribe from the area of Africa
that is now part of Gabon. The Baka pygmy tribe of the Congo basin are also
thought to have been among the first to learn the use of the plant. For 300
years it has been an integral part of the once-in-a-lifetime rite of passage
by which boys become men and any males who do not complete this initiation
test will forever be branded as girls.
And it certainly is a test. Candidates must chew about 100g of iboga root
shavings over a period of eight hours. They are washed and purified in the
river and when their legs give out they sit in the chapel and gaze into a
mirror. "Behind them sit their mothers or fathers of iboga, calming their
anxieties and listening carefully to their excited mumblings as the iboga
works upon them," wrote one observer. "They may already be experiencing a
sense of departure from self and of visionary encounter. Their mumblings may
convey important information to the entire membership."
The guide who stayed with the man on the blanket through every moment of his
inner journey was Dan Lieberman, a South African ethnobotanist but never an
addict. For $3000 he will take you on a 10-day initiation trip of your own.
I meet you at the airport and from that moment you don't have to do anything,"
he says. I stay with you all the time. When you take the ibogaine you are
in a super-aware state between sleeping and waking. Your body is in a deep
coma but your mind is completely aware. You work through all sorts of past
traumas. Some people do it for self-discovery, others to beat addiction."
Lieberman first encountered ibogaine when he was studying Bwiti religious
initiation rituals in Cameroon. These rituals involve consuming large amounts
of bark scraping from the iboga root. Initiates have described their extraordinary
experiences: they encountered menacing animals, met with higher spiritual
entities and talked to their ancestors. At the end, many said they had a sense
of the whole course of their lives.
While Lieberman works on his own and gives his client the actual plant material,
a more high-tech - and thus expensive - anti-addiction program using the ibogaine
extract is available from Dr. Deborah Mash. Professor of Neurology at the
University of Miami School of Medicine in Florida.
Another key player in the ibogaine story, she is the only academic to have
run preliminary trials on humans at a university, although she has never taken
it or any illegal drug. She has a state-of-the-art medical setup on St. Kitts
in the Caribbean, where, for $10,000, you can get proper screening, nurses,
heart monitors and a Harvard professor who oversees the proceedings and will
draw up your own personal rehabilitation program.
"We have had people who have been on really high doses of methadone, which
is a horrible drug to kick," says Mash. "Seventy two hours later they are
free of it and swimming in the Caribbean. It is an amazing treatment." 
Mash has now treated around 70 addicts - "our first one is still clean two
years later" - and a summary of 30 cases was presented at a landmark conference
on ibogaine in New York last November. Delegates heard that 25 of these 30
addicts had had no further cravings, not even any withdrawal symptoms after
24 hours. "lt doesn't work for absolutely everyone," says Mash, "but it is
a hell of a lot better than anything else we've got."
Her view is echoed by someone in the front line of the fight against drug
addiction and who believes in ibogaine's potential. "The normal treatment
for addiction is individual and group psychotherapy plus methadone," says
Patrick Walsh of the US National Probation service in New York, "but we are
not making good progress. If we can keep 10-20 % of youngsters off drugs just
for the time they are on probation, we figure that's a success." British figures,
for all the talk of a new drugs tzar, are not much better
The use of ibogaine as a cure for addiction is largely down to the efforts
of a New Yorker, one-time film student Howard Lotsof. In the 'swinging Sixties'
he was a heroin addict until someone handed him a mysterious drug, promising
it would get him really high. Lotsof had a remarkable time, seeing visions
and being taken back through his personal history, but what really amazed
him was that afterwards his craving for heroin had vanished.
As reported by those who have taken ibogaine, he suffered no withdrawal symptoms
- he didn't have to make an effort of will, he simply didn't want it any more.
Wondering if it was a fluke, he persuaded six of his addict friends to take
it. Five of them also came off heroin, and stayed off. There followed a period
of 'informal' testing to discover the optimum dosage and conditions under
which it should be taken before, in the mid-'80s, he patented ibogaine as
a cure for heroin, cocaine and alcohol addiction.
So how does ibogaine produce such a remarkable range of effects on the body?
Unfortunately, the most straightforward answer at the moment is that we don't
know exactly. Not least because the research into ibogaine has been done on
laboratory animals, which reveals little about the brain mechanisms involved
in intense visions of childhood. Another problem is that, despite years of
research, we don't even really know why people become addicted in the first
place.
However, we do know that ibogaine reduces the amount of dopamine, which is
one of the key chemical messengers in the brain. Research has shown that everything
we find enjoyable - from Morris dancing to sex - produces a burst of this
chemical that then hits one of the brain's pleasure centers, called nucleus
accumbens. It is thought that all addictions - cocaine, heroin, nicotine,
shopping - trigger such a dopamine rush to satisfy the addictive cravings.

Researchers at Albany Medical College in New York state, such as Professor
Stanley Glick, have made rats addicted to cocaine or morphine and succeeded
in training them to press a bar in their cage to get supplies of the drug.
They found that an injection of ibogaine decreased the amount of morphine
the rats gave them by 50 %. Like humans, some almost gave up completely, whilst
others needed several doses. One curious finding was that while ibogaine reduced
the amount of activity by male rats on cocaine or amphetamines, it actually
speeded up the female rats on the same drugs. But addiction is obviously not
just a mechanical matter of having a dopamine problem. Nearly everyone in
the ibogaine network stresses the importance of following up an ibogaine experience
with some sort of counseling. "What ibogaine does is to buy a window during
which the resistance of the body's defenses is softened," says US therapist
Sarah Emanon. "After taking ibogaine the person doesn't crave the drug and
feels great. But if they don't make use of that time to consolidate what they
have discovered, they are very likely to relapse."
Both the people who have studied the chemistry of ibogaine and those who are
interested in what it does psychologically conclude that it somehow resets
the brain and mind so they work more effectively. "It is almost as if ibogaine
overwhelms the system psychologically and emotionally with the hallucinations,"
says Emanon, "so the person cannot behave or interpret what is happening using
the old destructive patterns."
After researching ibogaine at a molecular level, Alan Leshner, director of
the US National Institute on Drug Abuse in Maryland, concludes: "There is
evidence to suggest that ibogaine treatment might result in the 'resetting'
or normalization of neuroadaptations related to sensitization or tolerance
induced by addiction."
Whatever the brain mechanisms turn out to be, ibogaine involves a dramatic
change in the approach to addiction. Previous attempts to fight drugs with
drugs have either involved trying to block the effect of the illegal drug
or find a substitute, but none have been effective. "Ibogaine presents a potential
new strategy for treating addiction to diverse drugs classes," concluded Professor
Piotr Popik of the US National Institutes of Health, Maryland in a major review
of the scientific literature on ibogaine.
So why isn't ibogaine part of every drug rehabilitation program, instead of,
for the most part, being administered surreptitiously in hotel rooms in America
and Amsterdam? "Although it does have remarkable properties," says Professor
Glick, "from the point of view of the medical establishment there are problems
with it."
"The original work on it was done by an ex-hippie and one-time drug addict
with no background in pharmacology. It's a naturally occurring plant alkaloid,
which no one knows how it works - and it is a powerful hallucinogen."

The image problem aside, such a remarkable cure for addiction should be a
big enough money spinner for the pharmaceutical companies to snap up. Glick,
one of the organizers of the New York conference, explains why it isn't. "Pharmaceutical
firms are not very interested in such anti-addiction drugs. Addiction has
got obvious negative associations and there is not nearly as much money there
as you might think. We only spend about $65m on developing addiction pharmacotherapy,
which is a fraction of the estimated $200 - $600m average cost of bringing
a single new drug to market."
One of the big mysteries of ibogaine is: how can a single dose apparently
keep on working in the body, months after it should have been broken down
by the liver and evacuated? Dr. Mash now thinks she knows the answer.
It seems that the liver turns ibogaine into something called noribogaine,
which stays in the body and behaves like a Prozac implant, raising the levels
of serotonin in the brain and keeping patients happier and free of cravings.
Mash currently plans to develop a noribogaine skin patch to help reformed
addicts stay clean.
Ibogaine and Regression 
Because of its ability to stimulate memories of vivid early experiences, ibogaine
has attracted the interest of therapists who are particularly interested in
regression. There have been no formal studies, but reports vary from positive
to very negative.
Therapist Sarah Emanon is someone who has found it very valuable. "I gathered
pictures from my childhood and I pored over them before the session. When
the effects of the drug came on, the emotions of the people in the pictures
- my father and mother, and my adopted father and mother started popping out
at me."
Going back. "I saw that my father was very well armored. I remembered being
a little girl and trying 'to get to him, but I couldn't reach this person.
Then I saw my current partner and saw how I couldn't get to him either. And
it just went boom, boom, boom - all the way back to my father."
"Then, I went back even further, to being with my adopted mother as an infant
while she was holding me. Then I smelled her, and it didn't feel right. I
didn't want to be near her. I was trying to get away but I didn't know how
to hold my head up. That's where I realized I retreated into myself."
"So here I am focusing on all the people in relationships, but there is no
communication either way. And I saw myself picking people who can't come out
of themselves because I can't come out of myself. This was the beginning of
owning my own process rather than projecting it onto others."
Ibogaine Trip - a Personal Account
When I ate iboga, I found myself taken by it up a long road in a deep forest
until I came to a barrier of black iron. At that barrier, unable to pass,
I saw a crowd of black persons also unable to pass. Suddenly my father descended
from above in the form of a bird. He gave to me then my iboga name, Onion
Messenger, and enabled me to fly up after him over the barrier of iron.
As we proceeded, the bird who was my father changed from black to white- first
his tail feathers, then all his plumage. We came then to a river the color
of blood, in the midst of which was a great snake of three colors - blue,
black and red. It closed its gaping mouth so that we could pass over it.
On the other side there was a crowd of people all in white. We passed through
and they shouted at us words of recognition until we arrived at another river,
all white. This we crossed by means of a giant chain of gold. On the other
side there were no trees, but only a grassy upland.
Return or die. On the top of the hill was a round house made entirely of glass
and built on one post only. Within I saw a man. The hair on his head piled
up in the form of a bishop's hat! He had a star on his breast, but oncoming
closer I saw that it was his heart in his chest beating. We moved around him,
and on the back of his neck there was a red cross tattooed. He had a long
beard.
Just then I looked up and saw a woman in the moon - a bayonet was piercing
her heart, from which a bright white fire was pouring forth. Then I felt a
pain in my shoulder. My father told me to return to Earth. I had gone far
enough. If I went farther I would not return.
Jerome Burne -- Focus Magazine, July 2000